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Major historical events often shape the way we live, and diseases in particular have often been a strong herald of change. From antibacterial brass doorknobs to broad, well-ventilated boulevards, the urban architecture of our cities have often been shaped by disease.
It was cholera that influenced the modern street grid, as 19th-century epidemics prompted the introduction of sewage systems that required the roads above them to be wider and straighter, along with new zoning laws to prevent overcrowding.