While powerful megatrends like global trade tensions, climate change, new technology innovations, and the current COVID-19 crisis impact all parts of the globe, the reality of those impacts – and therefore the necessary responses to them – are inherently driven by unique regional characteristics and the regional enabling environments. The Global Network of Advanced Manufacturing Hubs (AMHUBs) connects regional manufacturing ecosystems to help rapidly transform manufacturing to keep pace with the global megatrends that might otherwise create disruptions for manufacturers around the globe.